Update on the Protective Molecular Pathways Improving Pancreatic Beta-Cell Dysfunction

• Main Authors: Alessandra Puddu (Author), Roberta Sanguineti (Author), François Mach (Author), Franco Dallegri (Author), Giorgio Luciano Viviani (Author), Fabrizio Montecucco (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The primary function of pancreatic beta-cells is to produce and release insulin in response to increment in extracellular glucose concentrations, thus maintaining glucose homeostasis. Deficient beta-cell function can have profound metabolic consequences, leading to the development of hyperglycemia a...