Quantitation of bivalirudin, a novel anticoagulant peptide, in human plasma by LCâMS/MS: Method development, validation and application to pharmacokinetics

• Main Authors: Xiao-Jiao Li (Author), Yan-Tong Sun (Author), Lei Yin (Author), Xue-Ju Zhang (Author), Yan Yang (Author), J. Paul Fawcett (Author), Yi-Min Cui (Author), Jing-Kai Gu (Author)
• Format: Book
• Published: Elsevier, 2013-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A rapid and sensitive method based on liquid chromatographyâtandem mass spectrometry (LCâMS/MS) for the determination of a novel anticoagulant peptide bivalirudin in human plasma has been developed and validated. Plasma samples were precipitated protein with acetonitrile and re-extracted with dichlo...