Neuroprotective Effect of Ramipril Is Mediated by AT2 in a Mouse MODEL of Paclitaxel-Induced Peripheral Neuropathy

• Main Authors: Hichem Bouchenaki (Author), Amandine Bernard (Author), Flavien Bessaguet (Author), Simon Frachet (Author), Laurence Richard (Author), Franck Sturtz (Author), Laurent Magy (Author), Sylvie Bourthoumieu (Author), Claire Demiot (Author), Aurore Danigo (Author)
• Format: Book
• Published: MDPI AG, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Paclitaxel (PTX)-induced peripheral neuropathy (PIPN) induces numerous symptoms affecting patient quality of life, leading to decreased doses or even to cessation of anticancer therapy. Previous studies have reported that a widely used drug, ramipril, improves neuroprotection in several rodent model...