Proof-of-concept Studies for siRNA-mediated Gene Silencing for Coagulation Factors in Rat and Rabbit

• Main Authors: Zhu Chen (Author), Bin Luo (Author), Tian-Quan Cai (Author), Anil Thankappan (Author), Yiming Xu (Author), Weizhen Wu (Author), Jillian DiMuzio (Author), Traci Lifsted (Author), Marty DiPietro (Author), Jyoti Disa (Author), Bruce Ng (Author), Karen Leander (Author), Seth Clark (Author), Lizbeth Hoos (Author), Yuchen Zhou (Author), Nina Jochnowitz (Author), Christine Jachec (Author), Peter Szczerba (Author), Marian E Gindy (Author), Walter Strapps (Author), Laura Sepp-Lorenzino (Author), Dietmar A Seiffert (Author), Laura Lubbers (Author), Marija Tadin-Strapps (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study aimed at establishing feasibility of delivering short interfering RNA (siRNA) to target the coagulation cascade in rat and rabbit, two commonly used species for studying thrombosis and hemostasis. siRNAs that produced over 90% mRNA knockdown of rat plasma prekallikrein and rabbit F...