A study of intestinal absorption of bicyclol in rats: active efflux transport and metabolism as causes of its poor bioavailability
Purpose.To determine the possible mechanism of poor bioavailability of bicyclol, and clarify the respective contribution of P- glycoprotein (P-gp) and Cytochrome 3A (CYP3A). Methods. Rat in situ single-pass intestinal perfusion and Caco-2 cell monolayer model with selective inhibitors of CYP3A and P...
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| Main Authors: | , , , |
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| Format: | Book |
| Published: |
Frontiers Media S.A.,
2008-09-01T00:00:00Z.
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| Online Access: | Connect to this object online. |
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Internet
Connect to this object online.3rd Floor Main Library
| Call Number: |
A1234.567 |
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| Copy 1 | Available |