Targeting the Bromodomain of BRG-1/BRM Subunit of the SWI/SNF Complex Increases the Anticancer Activity of Temozolomide in Glioblastoma

Glioblastoma (GBM) is a deadly and incurable brain cancer with limited therapeutic options. PFI-3 is a small-molecule bromodomain (BRD) inhibitor of the BRM/BRG1 subunits of the SWI/SNF chromatin remodeling complex. The objective of this study is to determine the efficacy of PFI-3 as a potential GBM...

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Main Authors: Chuanhe Yang (Author), Yinan Wang (Author), Michelle M. Sims (Author), Yali He (Author), Duane D. Miller (Author), Lawrence M. Pfeffer (Author)
Format: Book
Published: MDPI AG, 2021-09-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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