Modulation of TRP Channel Activity by Hydroxylation and Its Therapeutic Potential
Two transient receptor potential (TRP) channels-TRPA1 and TRPV3-are post-translationally hydroxylated, resulting in oxygen-dependent regulation of channel activity. The enzymes responsible are the HIF prolyl hydroxylases (PHDs) and the asparaginyl hydroxylase factor inhibiting HIF (FIH). The PHDs an...
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MDPI AG,
2017-03-01T00:00:00Z.
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