Enhanced Tailored MicroRNA Sponge Activity of RNA Pol II-Transcribed TuD Hairpins Relative to Ectopically Expressed ciRS7-Derived circRNAs

• मुख्य लेखकों: Anne Kruse Hollensen (लेखक), Sofie Andersen (लेखक), Karina Hjorth (लेखक), Rasmus O. Bak (लेखक), Thomas B. Hansen (लेखक), Jørgen Kjems (लेखक), Lars Aagaard (लेखक), Christian Kroun Damgaard (लेखक), Jacob Giehm Mikkelsen (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2018-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

As key regulators of gene expression, microRNAs (miRNAs) have emerged as targets in basic experimentation and therapy. Administration of DNA-encoded RNA molecules, targeting miRNAs through base pairing, is one viable strategy for inhibiting specific miRNAs. A naturally occurring circular RNA (circRN...