Enhanced Tailored MicroRNA Sponge Activity of RNA Pol II-Transcribed TuD Hairpins Relative to Ectopically Expressed ciRS7-Derived circRNAs

• Main Authors: Anne Kruse Hollensen (Author), Sofie Andersen (Author), Karina Hjorth (Author), Rasmus O. Bak (Author), Thomas B. Hansen (Author), Jørgen Kjems (Author), Lars Aagaard (Author), Christian Kroun Damgaard (Author), Jacob Giehm Mikkelsen (Author)
• Format: Book
• Published: Elsevier, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As key regulators of gene expression, microRNAs (miRNAs) have emerged as targets in basic experimentation and therapy. Administration of DNA-encoded RNA molecules, targeting miRNAs through base pairing, is one viable strategy for inhibiting specific miRNAs. A naturally occurring circular RNA (circRN...