E. coli Endotoxin Modulates the Expression of Sirtuin Proteins in PBMC in Humans

• Main Authors: Angela Storka (Author), Gerhard Führlinger (Author), Martin Seper (Author), Lisa Wang (Author), Michael Jew (Author), Asha Leisser (Author), Michael Wolzt (Author)
• Format: Book
• Published: Hindawi Limited, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background. Sirtuin (SIRT) proteins are class I histone deacetylases displaying gene regulatory functions in inflammatory, cancer, and metabolic diseases. These SIRT actions involve the nuclear factor κB and its inhibitor IκB pathway. However, the regulation of SIRT in vivo is still unclear. Materia...