Layer‐by‐layer interleukin‐12 nanoparticles drive a safe and effective response in ovarian tumors

• Main Authors: Antonio E. Barberio (Author), Sean G. Smith (Author), Ivan S. Pires (Author), Sonia Iyer (Author), Ferenc Reinhardt (Author), Mariane B. Melo (Author), Heikyung Suh (Author), Robert A. Weinberg (Author), Darrell J. Irvine (Author), Paula T. Hammond (Author)
• Format: Book
• Published: Wiley, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Ovarian cancer is especially deadly, challenging to treat, and has proven refractory to known immunotherapies. Cytokine therapy is an attractive strategy to drive a proinflammatory immune response in immunologically cold tumors such as many high grade ovarian cancers; however, this strategy...