A Novel Single-Tube Next Generation Sequencing Assay for B-Cell Receptor Clonality Testing

• Main Authors: Landon Pastushok (Author), Shrutii Sarda (Author), Karen Mochoruk (Author), Wayne Hill (Author), Loni T. Pickle (Author), Michelle Toro (Author), Carolina Gonzalez (Author), Stephanie Ostresh (Author), Timothy J. Looney (Author), Chenchen Yang (Author), Julie Stakiw (Author), Mark J. Bosch (Author), Hadi Goubran (Author), C. Ronald Geyer (Author), Geoffrey M. Lowman (Author), John F. DeCoteau (Author)
• Format: Book
• Published: MDPI AG, 2024-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

B-cell neoplasms possess clonal B-cell receptor rearrangements (BCR clonotype lineages) that can be identified by sequencing the B-cell repertoire for use in diagnostics, risk stratification, and high-sensitivity monitoring. BCR somatic hypermutation (SHM) can result in clonality detection failure f...