Silencing of the GluN1-NMDA Glutamate Receptor Subunit by Intranasal siRNA Increases the Latency Time for Seizures in the Pilocarpine Rodent Model of Epilepsy

Temporal lobe epilepsy (TLE) is the most prevalent and treatment-refractory type of epilepsy. Among the different mechanisms associated with epileptogenesis, overstimulation of glutamatergic neurotransmission has been associated with the onset and progression of seizures in TLE. Experimental evidenc...

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Autors principals: Raphaela Gonçalves Barros Perri (Autor), Anieli Gaverio Mantello (Autor), Daiane Santos Rosa (Autor), Renê Oliveira Beleboni (Autor)
Format: Llibre
Publicat: MDPI AG, 2022-11-01T00:00:00Z.
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