Atractylenolide-1 Targets FLT3 to Regulate PI3K/AKT/HIF1-α Pathway to Inhibit Osteogenic Differentiation of Human Valve Interstitial Cells

Atractylenolide-1 (AT-1), a natural active ingredient extracted from Atractylodes macrocephala, was reported to have good anti-fibrotic and anti-inflammatory effects. Osteogenic changes induced by the inflammation of valve interstitial cells (VICs) play a role in the development of calcified aortic...

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Bibliographic Details
Main Authors: Jie Wang (Author), Penghua Zhang (Author), Jing Zhang (Author), Zhaohui Ma (Author), Xingqin Tian (Author), Yan Liu (Author), Guanghui Lv (Author), Linghang Qu (Author)
Format: Book
Published: Frontiers Media S.A., 2022-04-01T00:00:00Z.
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