Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia

• Main Authors: Takahiro Masuda (Author), Shosuke Iwamoto (Author), Satsuki Mikuriya (Author), Hidetoshi Tozaki-Saitoh (Author), Tomohiko Tamura (Author), Makoto Tsuda (Author), Kazuhide Inoue (Author)
• Format: Book
• Published: Elsevier, 2015-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Interferon regulatory factor-8 (IRF8) plays a crucial role in the transformation of microglia to a reactive state by regulating the expression of various genes. In the present study, we show that IRF1 is required for IRF8-induced gene expression in microglia. Peripheral nerve injury induced IRF1 gen...