Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia
Interferon regulatory factor-8 (IRF8) plays a crucial role in the transformation of microglia to a reactive state by regulating the expression of various genes. In the present study, we show that IRF1 is required for IRF8-induced gene expression in microglia. Peripheral nerve injury induced IRF1 gen...
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Elsevier,
2015-08-01T00:00:00Z.
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| LEADER | 00000 am a22000003u 4500 | ||
|---|---|---|---|
| 001 | doaj_da8b05c54d334f018357b3da005540e3 | ||
| 042 | |a dc | ||
| 100 | 1 | 0 | |a Takahiro Masuda |e author |
| 700 | 1 | 0 | |a Shosuke Iwamoto |e author |
| 700 | 1 | 0 | |a Satsuki Mikuriya |e author |
| 700 | 1 | 0 | |a Hidetoshi Tozaki-Saitoh |e author |
| 700 | 1 | 0 | |a Tomohiko Tamura |e author |
| 700 | 1 | 0 | |a Makoto Tsuda |e author |
| 700 | 1 | 0 | |a Kazuhide Inoue |e author |
| 245 | 0 | 0 | |a Transcription factor IRF1 is responsible for IRF8-mediated IL-1β expression in reactive microglia |
| 260 | |b Elsevier, |c 2015-08-01T00:00:00Z. | ||
| 500 | |a 1347-8613 | ||
| 500 | |a 10.1016/j.jphs.2015.08.002 | ||
| 520 | |a Interferon regulatory factor-8 (IRF8) plays a crucial role in the transformation of microglia to a reactive state by regulating the expression of various genes. In the present study, we show that IRF1 is required for IRF8-induced gene expression in microglia. Peripheral nerve injury induced IRF1 gene upregulation in the spinal microglia in an IRF8-dependent manner. IRF8 transduction in cultured microglia induced de novo gene expression of IRF1. Importantly, knockdown of the IRF1 gene in IRF8-transduced microglia prevented upregulation of interleukin-1β (IL-1β). Therefore, our findings suggest that expression of IL-1β is dependent on IRF1 in IRF8-expressing reactive microglia. | ||
| 546 | |a EN | ||
| 690 | |a Microglia | ||
| 690 | |a Interferon regulatory factor | ||
| 690 | |a IL-1β | ||
| 690 | |a Therapeutics. Pharmacology | ||
| 690 | |a RM1-950 | ||
| 655 | 7 | |a article |2 local | |
| 786 | 0 | |n Journal of Pharmacological Sciences, Vol 128, Iss 4, Pp 216-220 (2015) | |
| 787 | 0 | |n http://www.sciencedirect.com/science/article/pii/S1347861315001772 | |
| 787 | 0 | |n https://doaj.org/toc/1347-8613 | |
| 856 | 4 | 1 | |u https://doaj.org/article/da8b05c54d334f018357b3da005540e3 |z Connect to this object online. |