GMP-Compliant Radiosynthesis of [¹⁸F]GP1, a Novel PET Tracer for the Detection of Thrombi

• Main Authors: Verena Hugenberg (Author), Marion Zerna (Author), Mathias Berndt (Author), Reinhard Zabel (Author), Rainer Preuss (Author), Dirk Rolfsmeier (Author), Janet Wegener (Author), Henrik Fox (Author), Astrid Kassner (Author), Hendrik Milting (Author), Norman Koglin (Author), Andrew W. Stephens (Author), Jan F. Gummert (Author), Wolfgang Burchert (Author), Marcus-André Deutsch (Author)
• Format: Book
• Published: MDPI AG, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Thrombus formation and thromboembolic events play important roles in various cardiovascular pathologies. The key receptor involved in platelet aggregation is the fibrinogen receptor glycoprotein IIb/IIIa. [¹⁸F]GP1, a derivative of the GPIIb/IIIa antagonist elarofiban, is a spe...