QSAR studies of benzofuran/benzothiophene biphenyl derivatives as inhibitors of PTPase-1B
Objectives : Insulin resistance is associated with a defect in protein tyrosine phosphorylation in the insulin signal transduction cascade. The PTPase enzyme dephosphorylates the active form of the insulin receptor and thus attenuates its tyrosine kinase activity, therefore, the need for a potent PT...
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Wolters Kluwer Medknow Publications,
2010-01-01T00:00:00Z.
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