Bioanalysis of the Ex Vivo Labile PACE4 Inhibitory Peptide Ac-[<span style="font-variant: small-caps">d-</span>Leu]LLLRVK-Amba in Whole Blood Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry Quantification

• Main Authors: Max Sauter (Author), Jonas Haag (Author), Cindy Bay (Author), Florian Leuschner (Author), Walter E. Haefeli (Author), Tim Christian Kuhn (Author), Jürgen Burhenne (Author)
• Format: Book
• Published: MDPI AG, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The calcium-dependent serine endoprotease PACE4 is evaluated as a therapeutic target for prostate cancer. The peptide Ac-[<span style="font-variant: small-caps;">d</span>-Leu]LLLRVK-amba inhibits PACE4 with high affinity and has shown efficacy in preclinical mice xenograft mode...