Cathepsin D-Managing the Delicate Balance

• Main Authors: Olja Mijanovic (Author), Anastasiia I. Petushkova (Author), Ana Brankovic (Author), Boris Turk (Author), Anna B. Solovieva (Author), Angelina I. Nikitkina (Author), Sergey Bolevich (Author), Peter S. Timashev (Author), Alessandro Parodi (Author), Andrey A. Zamyatnin (Author)
• Format: Book
• Published: MDPI AG, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lysosomal proteases play a crucial role in maintaining cell homeostasis. Human cathepsin D manages protein turnover degrading misfolded and aggregated proteins and favors apoptosis in the case of proteostasis disruption. However, when cathepsin D regulation is affected, it can contribute to numerous...