Discovery and characterization of a new class of NAD+-independent SIRT1 activators

• Main Authors: Sara Della Torre (Author), Giulia Dell'Omo (Author), Jessica Dellavedova (Author), Luca Palazzolo (Author), Eugenio Scanziani (Author), Ivano Eberini (Author), Andrea Pinto (Author), Nico Mitro (Author), Paola Conti (Author), Alessandro Villa (Author), Paolo Ciana (Author)
• Format: Book
• Published: Elsevier, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The activity of sirtuin 1 (SIRT1, a member of the NAD+-dependent deacetylases family) decreases during aging as NAD+ levels naturally decline, thus increasing the risk of several age-associated diseases. Several sirtuin-activating compounds (STACs) have been developed to counteract the age-associate...