Human Host Defense Peptide LL-37 Suppresses TNFα-Mediated Matrix Metalloproteinases MMP9 and MMP13 in Human Bronchial Epithelial Cells

• Main Authors: Anthony Altieri (Author), Courtney Lynn Marshall (Author), Padmanie Ramotar (Author), Dylan Lloyd (Author), Mahadevappa Hemshekhar (Author), Victor Spicer (Author), Anne M. van der Does (Author), Neeloffer Mookherjee (Author)
• Format: Book
• Published: Karger Publishers, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: TNFα-inducible matrix metalloproteinases play a critical role in the process of airway remodeling in respiratory inflammatory disease including asthma. The cationic host defense peptide LL-37 is elevated in the lungs during airway inflammation. However, the impact of LL-37 on TNFα-driv...