Human Host Defense Peptide LL-37 Suppresses TNFα-Mediated Matrix Metalloproteinases MMP9 and MMP13 in Human Bronchial Epithelial Cells

• Egile Nagusiak: Anthony Altieri (Egilea), Courtney Lynn Marshall (Egilea), Padmanie Ramotar (Egilea), Dylan Lloyd (Egilea), Mahadevappa Hemshekhar (Egilea), Victor Spicer (Egilea), Anne M. van der Does (Egilea), Neeloffer Mookherjee (Egilea)
• Formatua: Liburua
• Argitaratua: Karger Publishers, 2024-03-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Introduction: TNFα-inducible matrix metalloproteinases play a critical role in the process of airway remodeling in respiratory inflammatory disease including asthma. The cationic host defense peptide LL-37 is elevated in the lungs during airway inflammation. However, the impact of LL-37 on TNFα-driv...