BET Protein Inhibitor JQ1 Modulates Mitochondrial Dysfunction and Oxidative Stress Induced by Chronic Kidney Disease

• المؤلفون الرئيسيون: Sandra Rayego-Mateos (مؤلف), Pamela Basantes (مؤلف), José Luis Morgado-Pascual (مؤلف), Beatriz Brazal Prieto (مؤلف), Beatriz Suarez-Alvarez (مؤلف), Alberto Ortiz (مؤلف), Carlos Lopez-Larrea (مؤلف), Marta Ruiz-Ortega (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2023-05-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Among the mechanisms involved in the progression of kidney disease, mitochondrial dysfunction has special relevance. Epigenetic drugs such as inhibitors of extra-terminal domain proteins (iBET) have shown beneficial effects in experimental kidney disease, mainly by inhibiting proliferative and infla...