Development and evaluation of candidate subunit vaccine and novel antitoxin against botulinum neurotoxin serotype E

• Main Authors: Dan-Yang Shi (Author), Fu-Jia Liu (Author), Yun-Yun Mao (Author), Rong-Tian Cui (Author), Jian-Sheng Lu (Author), Yun-Zhou Yu (Author), Xiao-Jie Dong (Author), Zhi-Xin Yang (Author), Zhi-Wei Sun (Author), Xiao-Bin Pang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Botulinum neurotoxins (BoNTs) are among the most toxic proteins. Vaccination is an effective strategy to prevent botulism. To generate a vaccine suitable for human use, a recombinant non-His-tagged isoform of the Hc domain of botulinum neurotoxin serotype E (rEHc) was expressed in Escherichia coli a...