Model‐based simulation to support the approval of isatuximab alone or with dexamethasone for the treatment of relapsed/refractory multiple myeloma in Japanese patients

• Autori principali: Hoai‐Thu Thai (Autore), Kimiko Koiwai (Autore), Yoshihisa Shitara (Autore), Hirotaka Kazama (Autore), Jean‐Baptiste Fau (Autore), Dorothée Semiond (Autore), Christine Veyrat‐Follet (Autore)
• Natura: Libro
• Pubblicazione: Wiley, 2023-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract This study aimed to support dosing regimen selection for isatuximab as a single agent or in combination with dexamethasone for Japanese patients with relapsed/refractory multiple myeloma (RRMM). A joint model characterizing the dynamics of serum M‐protein kinetics and its association with p...