Novel prognostic markers within the CD44‐stromal ligand network in pancreatic cancer

• Main Authors: Oskar Franklin (Author), Ola Billing (Author), Daniel Öhlund (Author), Anette Berglund (Author), Carl Herdenberg (Author), Wanzhong Wang (Author), Urban Hellman (Author), Malin Sund (Author)
• Format: Book
• Published: Wiley, 2019-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The dense stroma in pancreatic cancer tumours is rich in secreted extracellular matrix proteins and proteoglycans. Secreted hyaluronan, osteopontin and type IV collagen sustain oncogenic signalling by interactions with CD44s and its variant isoform CD44v6 on cancer cell membranes. Although...