The xenobiotic transporter ABCC4/MRP4 promotes epithelial mesenchymal transition in pancreatic cancer

• Egile Nagusiak: S. N. Gancedo (Egilea), A. Sahores (Egilea), N. Gómez (Egilea), N. Di Siervi (Egilea), M. May (Egilea), A. Yaneff (Egilea), M. G. de Sousa Serro (Egilea), N. Fraunhoffer (Egilea), N. Dusetti (Egilea), J. Iovanna (Egilea), C. Shayo (Egilea), C. A. Davio (Egilea), B. González (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

The xenobiotic transporter ABCC4/MRP4 is highly expressed in pancreatic ductal adenocarcinoma (PDAC) and correlates with a more aggressive phenotype and metastatic propensity. Here, we show that ABCC4 promotes epithelial-mesenchymal transition (EMT) in PDAC, a hallmark process involving the acquisit...