TNF-α and Microglial Hormetic Involvement in Neurological Health & Migraine

• Main Authors: Richard P. Kraig (Author), Heidi M. Mitchell (Author), Barbara Christie-Pope (Author), Phillip E. Kunkler (Author), David M. White (Author), Ya-Ping Tang (Author), George Langan (Author)
• Format: Book
• Published: SAGE Publishing, 2010-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Environmental enrichment, i.e., increased intellectual, social, and physical activity makes brain more resilient to subsequent neurological disease. The mechanisms for this effect remain incompletely defined, but evidence shows tumor necrosis factor-alpha (TNF-α) is involved. TNF-α, at acutely high...