Adipose tissue peroxisomal lipid synthesis orchestrates obesity and insulin resistance through LXR-dependent lipogenesis

• Main Authors: Brian Kleiboeker (Author), Anyuan He (Author), Min Tan (Author), Dongliang Lu (Author), Donghua Hu (Author), Xuejing Liu (Author), Parniyan Goodarzi (Author), Fong-Fu Hsu (Author), Babak Razani (Author), Clay F. Semenkovich (Author), Irfan J. Lodhi (Author)
• Format: Book
• Published: Elsevier, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Adipose tissue mass is maintained by a balance between lipolysis and lipid storage. The contribution of adipose tissue lipogenesis to fat mass, especially in the setting of high-fat feeding, is considered minor. Here we investigated the effect of adipose-specific inactivation of the perox...