Role of transglutaminase 2 in promoting biglycan synthesis in idiopathic gingival fibromatosis

• Main Authors: Yurika Ninomiya (Author), Shinji Matsuda (Author), Shigeki Suzuki (Author), Shizu Hirata-Tsuchiya (Author), Tomoya Ueda (Author), Fuminori Nakashima (Author), Keisuke Yasuda (Author), Shogo Shimada (Author), Takumi Memida (Author), Tetsuya Yoshimoto (Author), Satoru Yamada (Author), Kazuhisa Ouhara (Author), Noriyoshi Mizuno (Author)
• Format: Book
• Published: BMC, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background This study aimed to elucidate the pathogenesis of idiopathic gingival fibromatosis (IGF). Methods Human gingival fibroblasts (hGFs) were isolated from patients with IGF and periodontitis. Differential gene expression in the hGFs was analyzed using RNA sequencing. Extracellular ma...