Pharmaceutical Effects of Inhibiting the Soluble Epoxide Hydrolase in Canine Osteoarthritis

• Main Authors: Cindy B. McReynolds (Author), Sung Hee Hwang (Author), Jun Yang (Author), Debin Wan (Author), Karen Wagner (Author), Christophe Morisseau (Author), Dongyang Li (Author), William K. Schmidt (Author), Bruce D. Hammock (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Osteoarthritis (OA) is a degenerative joint disease that causes pain and bone deterioration driven by an increase in prostaglandins (PGs) and inflammatory cytokines. Current treatments focus on inhibiting prostaglandin production, a pro-inflammatory lipid metabolite, with NSAID drugs; however, other...