Predicting non-chemotherapy drug-induced agranulocytosis toxicity through ensemble machine learning approaches

• Main Authors: Xiaojie Huang (Author), Xiaochun Xie (Author), Shaokai Huang (Author), Shanshan Wu (Author), Lina Huang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Agranulocytosis, induced by non-chemotherapy drugs, is a serious medical condition that presents a formidable challenge in predictive toxicology due to its idiosyncratic nature and complex mechanisms. In this study, we assembled a dataset of 759 compounds and applied a rigorous feature selection pro...