A quality by design approach for the development of lyophilized liposomes with simvastatin

• Main Authors: Alina Porfire (Author), Dana Maria Muntean (Author), Lucia Rus (Author), Bianca Sylvester (Author), Ioan Tomuţă (Author)
• Format: Book
• Published: Elsevier, 2017-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lyophilization is used to ensure an increased shelf-life of liposomes, by preserving them in dry state, more stable than the aqueous dispersions. When stored as aqueous systems, the encapsulated drugs are released and the liposomes might aggregate or fuse. The aim of this study was to develop and op...