BET Protein Inhibitor JQ1 Ameliorates Experimental Peritoneal Damage by Inhibition of Inflammation and Oxidative Stress

• Main Authors: Vanessa Marchant (Author), Flavia Trionfetti (Author), Lucia Tejedor-Santamaria (Author), Sandra Rayego-Mateos (Author), Dante Rotili (Author), Giulio Bontempi (Author), Alessandro Domenici (Author), Paolo Menè (Author), Antonello Mai (Author), Catalina Martín-Cleary (Author), Alberto Ortiz (Author), Adrian M. Ramos (Author), Raffaele Strippoli (Author), Marta Ruiz-Ortega (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Peritoneal dialysis (PD) is a current replacement therapy for end-stage kidney diseases (ESKDs). However, long-term exposure to PD fluids may lead to damage of the peritoneal membrane (PM) through mechanisms involving the activation of the inflammatory response and mesothelial-to-mesenchymal transit...