Design, synthesis, and biological evaluation of triazole-pyrimidine-methylbenzonitrile derivatives as dual A2A/A2B adenosine receptor antagonists

• Main Authors: Zhi Li (Author), Lijuan Kou (Author), Xinzhen Fu (Author), Zeping Xie (Author), Maolei Xu (Author), Lin Guo (Author), Tiantian Lin (Author), Shizhou Gong (Author), Shumin Zhang (Author), Ming Liu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A series of novel dual A2A/A2B AR antagonists based on the triazole-pyrimidine-methylbenzonitrile core were designed and synthesised. The A2A AR antagonist cAMP functional assay results were encouraging for most target compounds containing quinoline or its open-ring bioisosteres. In addition, compou...