Integrating Clopidogrel's First-Pass Effect in a Joint Semi-Physiological Population Pharmacokinetic Model of the Drug and Its Inactive Carboxylic Acid Metabolite

• Päätekijät: Zorica Pejčić (Tekijä), Valentina Topić Vučenović (Tekijä), Branislava Miljković (Tekijä), Katarina M. Vučićević (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2024-05-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Clopidogrel (CLO), a pro-drug for preventing thrombotic events, undergoes rapid absorption and extensive metabolism, with approximately 85-90% converted to an inactive carboxylic acid metabolite (CLO-CA) and the remaining to an active thiol (CLO-TH). Few pharmacokinetic models for the drug and its m...