The <i>Trypanosoma brucei</i>-Derived Ketoacids, Indole Pyruvate and Hydroxyphenylpyruvate, Induce HO-1 Expression and Suppress Inflammatory Responses in Human Dendritic Cells

• Main Authors: Hannah K. Fitzgerald (Author), Sinead A. O'Rourke (Author), Eva Desmond (Author), Nuno G. B. Neto (Author), Michael G. Monaghan (Author), Miriam Tosetto (Author), Jayne Doherty (Author), Elizabeth J. Ryan (Author), Glen A. Doherty (Author), Derek P. Nolan (Author), Jean M. Fletcher (Author), Aisling Dunne (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The extracellular parasite and causative agent of African sleeping sickness <i>Trypanosoma brucei</i> (<i>T. brucei</i>) has evolved a number of strategies to avoid immune detection in the host. One recently described mechanism involves the conversion of host-derived amino ac...