Molecular characterization of sessile serrated adenoma/polyps with dysplasia/carcinoma based on immunohistochemistry, next-generation sequencing, and microsatellite instability testing: a case series study

• Main Authors: Takashi Murakami (Author), Yoichi Akazawa (Author), Noboru Yatagai (Author), Takafumi Hiromoto (Author), Noriko Sasahara (Author), Tsuyoshi Saito (Author), Naoto Sakamoto (Author), Akihito Nagahara (Author), Takashi Yao (Author)
• Format: Book
• Published: BMC, 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Colorectal sessile serrated adenoma/polyps (SSA/Ps) are considered early precursor lesions in the serrated neoplasia pathway. Recent studies have shown associations of SSA/Ps with lost MLH1 expression, a CpG island methylator phenotype, and BRAF mutations. However, the molecular...