Molecular characterization of sessile serrated adenoma/polyps with dysplasia/carcinoma based on immunohistochemistry, next-generation sequencing, and microsatellite instability testing: a case series study

• Principais autores: Takashi Murakami (Autor), Yoichi Akazawa (Autor), Noboru Yatagai (Autor), Takafumi Hiromoto (Autor), Noriko Sasahara (Autor), Tsuyoshi Saito (Autor), Naoto Sakamoto (Autor), Akihito Nagahara (Autor), Takashi Yao (Autor)
• Formato: Livro
• Publicado em: BMC, 2018-11-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Abstract Background Colorectal sessile serrated adenoma/polyps (SSA/Ps) are considered early precursor lesions in the serrated neoplasia pathway. Recent studies have shown associations of SSA/Ps with lost MLH1 expression, a CpG island methylator phenotype, and BRAF mutations. However, the molecular...