Identification of the metabolites of ivermectin in humans

• Main Authors: Phornpimon Tipthara (Author), Kevin C. Kobylinski (Author), Markus Godejohann (Author), Borimas Hanboonkunupakarn (Author), Alison Roth (Author), John H. Adams (Author), Nicholas J. White (Author), Podjanee Jittamala (Author), Nicholas P. J. Day (Author), Joel Tarning (Author)
• Format: Book
• Published: Wiley, 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Mass drug administration of ivermectin has been proposed as a possible malaria elimination tool. Ivermectin exhibits a mosquito‐lethal effect well beyond its biological half‐life, suggesting the presence of active slowly eliminated metabolites. Human liver microsomes, primary human hepatocy...