Does Proteosome Inhibition Decrease or Accelerate Toxin-Induced Dopaminergic Neurodegeneration?

• Egile Nagusiak: Rieko Setsuie (Egilea), Tomohiro Kabuta (Egilea), Keiji Wada (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2005-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Parkinson's disease (PD) is pathologically characterized by dopaminergic (DA) cell death and the presence of Lewy bodies (LB) in the brain. α-Synuclein (α-syn) and ubiquitin (Ub) are the major components of LB, however, the process of their accumulation and their relationship to DA cell loss ha...