Oxidative Damage Induced by Phototoxic Pheophorbide a 17-Diethylene Glycol Ester Encapsulated in PLGA Nanoparticles

• Main Authors: Mariia R. Mollaeva (Author), Elena Nikolskaya (Author), Veronika Beganovskaya (Author), Maria Sokol (Author), Margarita Chirkina (Author), Sergey Obydennyi (Author), Dmitry Belykh (Author), Olga Startseva (Author), Murad D. Mollaev (Author), Nikita Yabbarov (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pheophorbide a 17-diethylene glycol ester (XL-8), is a promising high-active derivative of known photosensitizer chlorin e6 used in photodynamic therapy. However, high lipophilicity and poor tumor accumulation limit XL-8 therapeutic application. We developed a novel XL-8 loaded with poly(D,L-lactide...