Evaluation and Optimization of Blood Micro-Sampling Methods: Serial Sampling in a Cross-Over Design from an Individual Mouse

• Main Authors: Nita J Patel (Author), Enaksha Wickremsinhe (Author), Yu-Hua Hui (Author), Alexandar Barr (Author), Nicholas Masterson (Author), Kenneth Ruterbories (Author), Jennifer Weller (Author), Jennifer Hanes (Author), Tom Kern (Author), Everett Perkins (Author)
• Format: Book
• Published: Frontiers Media S.A., 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: Current practices applied to mouse pharmacokinetic (PK) studies often use large numbers of animals with sporadic or composite sampling that inadequately describe PK profiles.  The purpose of this work was to evaluate and optimize blood microsampling techniques coupled with dried blood spot...