Effect of reduced versus usual lipid emulsion dosing on bilirubin neurotoxicity and neurodevelopmental impairment in extremely preterm infants: study protocol for a randomized controlled trial

• Main Authors: Lindsay F. Holzapfel (Author), Cody Arnold (Author), Jon E. Tyson (Author), Steven M. Shapiro (Author), Eric W. Reynolds (Author), Claudia Pedroza (Author), Emily K. Stephens (Author), Alan Kleinfeld (Author), Andrew H. Huber (Author), Matthew A. Rysavy (Author), Maria del Mar Romero Lopez (Author), Amir M. Khan (Author)
• Format: Book
• Published: BMC, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Bilirubin neurotoxicity (BN) occurs in premature infants at lower total serum bilirubin levels than term infants and causes neurodevelopmental impairment. Usual dose lipid infusions in preterm infants may increase free fatty acids sufficiently to cause bilirubin displacement from...