Rapamycin treatment induces tubular proteinuria: role of megalin-mediated protein reabsorption

• Main Authors: Rodrigo A. S. Peres (Author), Diogo B. Peruchetti (Author), Rodrigo P. Silva-Aguiar (Author), Douglas E. Teixeira (Author), Carlos P. Gomes (Author), Christina M. Takiya (Author), Ana Acacia S. Pinheiro (Author), Celso Caruso-Neves (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Rapamycin is an immunosuppressor that acts by inhibiting the serine/threonine kinase mechanistic target of rapamycin complex 1. Therapeutic use of rapamycin is limited by its adverse effects. Proteinuria is an important marker of kidney damage and a risk factor for kidney diseases prog...