Effect of Antioxidants in Medicinal Products on Intestinal Drug Transporters

• Main Authors: Chetan P. Kulkarni (Author), Jia Yang (Author), Megan L. Koleske (Author), Giovanni Lara (Author), Khondoker Alam (Author), Andre Raw (Author), Bhagwant Rege (Author), Liang Zhao (Author), Dongmei Lu (Author), Lei Zhang (Author), Lawrence X. Yu (Author), Robert A. Lionberger (Author), Kathleen M. Giacomini (Author), Deanna L. Kroetz (Author), Sook Wah Yee (Author)
• Format: Book
• Published: MDPI AG, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The presence of mutagenic and carcinogenic N-nitrosamine impurities in medicinal products poses a safety risk. While incorporating antioxidants in formulations is a potential mitigation strategy, concerns arise regarding their interference with drug absorption by inhibiting intestinal drug transport...