Porous Nanostructure, Lipid Composition, and Degree of Drug Supersaturation Modulate In Vitro Fenofibrate Solubilization in Silica-Lipid Hybrids

• Päätekijät: Ruba Almasri (Tekijä), Paul Joyce (Tekijä), Hayley B. Schultz (Tekijä), Nicky Thomas (Tekijä), Kristen E. Bremmell (Tekijä), Clive A. Prestidge (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: MDPI AG, 2020-07-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

The unique nanostructured matrix obtained by silica-lipid hybrids (SLHs) is well known to improve the dissolution, absorption, and bioavailability of poorly water-soluble drugs (PWSDs). The aim of this study was to investigate the impact of: (i) drug load: 3-22.7% <i>w/w</i>, (ii) lipid...