Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts

Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts

In fibrosis remodelling of ECM leads to changes in composition and stiffness. Such changes can have a major impact on cell functions including proliferation, secretory profile and differentiation. Several studies have reported that fibrosis is characterised by increased senescence and accumulating e...

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Main Authors: Kaj E. C. Blokland (Author), Mehmet Nizamoglu (Author), Habibie Habibie (Author), Theo Borghuis (Author), Michael Schuliga (Author), Barbro N. Melgert (Author), Darryl A. Knight (Author), Corry-Anke Brandsma (Author), Simon D. Pouwels (Author), Janette K. Burgess (Author)
Format: Book
Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
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3rd Floor Main Library

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