Substrate stiffness engineered to replicate disease conditions influence senescence and fibrotic responses in primary lung fibroblasts

• Main Authors: Kaj E. C. Blokland (Author), Mehmet Nizamoglu (Author), Habibie Habibie (Author), Theo Borghuis (Author), Michael Schuliga (Author), Barbro N. Melgert (Author), Darryl A. Knight (Author), Corry-Anke Brandsma (Author), Simon D. Pouwels (Author), Janette K. Burgess (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In fibrosis remodelling of ECM leads to changes in composition and stiffness. Such changes can have a major impact on cell functions including proliferation, secretory profile and differentiation. Several studies have reported that fibrosis is characterised by increased senescence and accumulating e...