Hypoxia-Preconditioned Wharton's Jelly-Derived Mesenchymal Stem Cells Mitigate Stress-Induced Apoptosis and Ameliorate Human Islet Survival and Function in Direct Contact Coculture System

• Main Authors: Somayeh Keshtkar (Author), Maryam Kaviani (Author), Zahra Jabbarpour (Author), Fatemeh Sabet Sarvestani (Author), Mohammad Hossein Ghahremani (Author), Elaheh Esfandiari (Author), Mahdokht Hossein Aghdaei (Author), Saman Nikeghbalian (Author), Alireza Shamsaeefar (Author), Bita Geramizadeh (Author), Negar Azarpira (Author)
• Format: Book
• Published: Hindawi Limited, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Protection of isolated pancreatic islets against hypoxic and oxidative damage-induced apoptosis is essential during a pretransplantation culture period. A beneficial approach to maintain viable and functional islets is the coculture period with mesenchymal stem cells (MSCs). Hypoxia preconditioning...