Investigating novel thiazolyl-indazole derivatives as scaffolds for SARS-CoV-2 MPro inhibitors

• Main Authors: Justin Airas (Author), Catherine A. Bayas (Author), Abdellah N'Ait Ousidi (Author), Moulay Youssef Ait Itto (Author), Aziz Auhmani (Author), Mohamed Loubidi (Author), M'hamed Esseffar (Author), Julie A. Pollock (Author), Carol A. Parish (Author)
• Format: Book
• Published: Elsevier, 2022-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

COVID-19 is a global pandemic caused by infection with the SARS-CoV-2 virus. Remdesivir, a SARS-CoV-2 RNA polymerase inhibitor, is the only drug to have received widespread approval for treatment of COVID-19. The SARS-CoV-2 main protease enzyme (MPro), essential for viral replication and transcripti...