mTORC2 and AMPK differentially regulate muscle triglyceride content via Perilipin 3

• Main Authors: Maximilian Kleinert (Author), Benjamin L. Parker (Author), Rima Chaudhuri (Author), Daniel J. Fazakerley (Author), Annette Serup (Author), Kristen C. Thomas (Author), James R. Krycer (Author), Lykke Sylow (Author), Andreas M. Fritzen (Author), Nolan J. Hoffman (Author), Jacob Jeppesen (Author), Peter Schjerling (Author), Markus A. Ruegg (Author), Bente Kiens (Author), David E. James (Author), Erik A. Richter (Author)
• Format: Book
• Published: Elsevier, 2016-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: We have recently shown that acute inhibition of both mTOR complexes (mTORC1 and mTORC2) increases whole-body lipid utilization, while mTORC1 inhibition had no effect. Therefore, we tested the hypothesis that mTORC2 regulates lipid metabolism in skeletal muscle. Methods: Body composition,...